Regulatory T cells predict the time to initial treatment in early stage chronic lymphocytic leukemia.

@article{Weiss2011RegulatoryTC,
  title={Regulatory T cells predict the time to initial treatment in early stage chronic lymphocytic leukemia.},
  author={Luk{\'a}s Weiss and Thomas Melchardt and Alexander Egle and Christoph Grabmer and Richard Greil and Ingeborg Tinhofer},
  journal={Cancer},
  year={2011},
  volume={117 10},
  pages={
          2163-9
        }
}
BACKGROUND Early stage chronic lymphocytic leukemia is characterized by a highly variable course of disease. Because it is believed that regulatory T cells (T(regs) ) are potent suppressors of antitumor immunity, the authors hypothesized that increased T(regs) may favor disease progression. METHODS T(reg) levels (cluster of differentiation 3 [CD3]-positive, [CD4]-positive, CD25-positive, and CD127-negative) in peripheral blood from 102 patients were analyzed by flow cytometry. Statistical… CONTINUE READING
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