Regulatory T cells mediate maternal tolerance to the fetus

  title={Regulatory T cells mediate maternal tolerance to the fetus},
  author={Varuna R. Aluvihare and Marinos Kallikourdis and Alexander G. Betz},
  journal={Nature Immunology},
Pregnancy constitutes a major challenge to the maternal immune system, as it has to tolerate the persistence of paternal alloantigen. Although localized mechanisms contribute to fetal evasion from immune attack, maternal alloreactive lymphocytes persist. We demonstrate here an alloantigen-independent, systemic expansion of the maternal CD25+ T cell pool during pregnancy and show that this population contains dominant regulatory T cell activity. In addition to their function in suppressing… CONTINUE READING
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