Regulatory T cells limit induction of protective immunity and promote immune pathology following intestinal helminth infection.

@article{Sawant2014RegulatoryTC,
  title={Regulatory T cells limit induction of protective immunity and promote immune pathology following intestinal helminth infection.},
  author={Deepali V. Sawant and David Gravano and Peter Vogel and Paul R. Giacomin and David Artis and Dario A A Vignali},
  journal={Journal of immunology},
  year={2014},
  volume={192 6},
  pages={2904-12}
}
Foxp3(+) regulatory T cells (Tregs) have a well-characterized role in limiting autoimmunity and dampening deleterious immune responses. However, a potential consequence of the immunosuppressive function of Tregs can be the limitation of protective immunity to infectious pathogens. Parasitic infections are a potent stimulus for the generation of Treg responses, which may be beneficial to both the parasite and the host by promoting persistence of infection and limiting immune-mediated pathology… CONTINUE READING

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