Regulatory T cells inhibit dendritic cells by lymphocyte activation gene-3 engagement of MHC class II.

@article{Liang2008RegulatoryTC,
  title={Regulatory T cells inhibit dendritic cells by lymphocyte activation gene-3 engagement of MHC class II.},
  author={Bitao Liang and Craig Workman and Janine B Lee and Claude Chew and Benjamin M. Dale and Lucrezia Colonna and Marcella C Flores and Nianyu Li and Edina Schweighoffer and Steven Greenberg and Victor L. J. Tybulewicz and Dario A A Vignali and Raphael Clynes},
  journal={Journal of immunology},
  year={2008},
  volume={180 9},
  pages={5916-26}
}
Lymphocyte activation gene-3 (LAG-3) is a CD4-related transmembrane protein expressed by regulatory T cells that binds MHC II on APCs. It is shown in this study that during Treg:DC interactions, LAG-3 engagement with MHC class II inhibits DC activation. MHC II cross-linking by agonistic Abs induces an ITAM-mediated inhibitory signaling pathway, involving FcgammaRgamma and ERK-mediated recruitment of SHP-1 that suppresses dendritic cell maturation and immunostimulatory capacity. These data… CONTINUE READING

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