Regulatory T cells induce a privileged tolerant microenvironment at the fetal-maternal interface.

@article{Zenclussen2006RegulatoryTC,
  title={Regulatory T cells induce a privileged tolerant microenvironment at the fetal-maternal interface.},
  author={Ana Claudia Zenclussen and Katrin Gerlof and Mar{\'i}a Laura Zenclussen and Stefanie Ritschel and Annarosa Zambon Bertoja and Stefan Fest and Shigeto Hontsu and Satoshi Ueha and Kouji Matsushima and Joachim Leber and H P Volk},
  journal={European journal of immunology},
  year={2006},
  volume={36 1},
  pages={82-94}
}
The mechanisms underlying immune tolerance during pregnancy are poorly understood. In this regard, Treg seem to play an important role in mediating maternal tolerance to the fetus. We proposed a crucial role of T regulatory cells (Treg) in avoiding immunological rejection of the fetus after observing diminished number and function of Treg in abortion-prone mice. We further confirmed the protective role of Treg during pregnancy by transferring pregnancy-induced Treg into abortion-prone mice… CONTINUE READING
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