Regulatory T-cells in type 1 diabetes.

  title={Regulatory T-cells in type 1 diabetes.},
  author={Amy E. Juedes and Matthias G von Herrath},
  journal={Diabetes/metabolism research and reviews},
  volume={20 6},
Type 1 diabetes is a T-cell-mediated autoimmune disease, resulting in destruction of the insulin-producing beta cells in the pancreas. Disease progression is thought to involve the action of T-cells, particularly those producing Th1-type cytokines. Given the complexity in understanding the precise etiology of autoimmune diseases, the diversity of autoantigens, and the variability that exists between individual patients, it might be very difficult to eliminate autoaggressive T-cell responses… CONTINUE READING