Regulatory T cells in transplantation tolerance.

  title={Regulatory T cells in transplantation tolerance.},
  author={Kathryn J. Wood and Shimon Sakaguchi},
  journal={Nature reviews. Immunology},
  volume={3 3},
The identification and characterization of regulatory T (T(Reg)) cells that can control immune responsiveness to alloantigens have opened up exciting opportunities for new therapies in transplantation. After exposure to alloantigens in vivo, alloantigen-specific immunoregulatory activity is enriched in a population of CD4+ T cells that express high levels of CD25. In vivo, common mechanisms seem to underpin the activity of CD4+CD25+ T(Reg) cells in both naive and manipulated hosts. However, the… CONTINUE READING
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