Regulatory T cells in transplantation: transferring mouse studies to the clinic.

@article{Long2009RegulatoryTC,
  title={Regulatory T cells in transplantation: transferring mouse studies to the clinic.},
  author={Elaine T. Long and Kathryn J. Wood},
  journal={Transplantation},
  year={2009},
  volume={88 9},
  pages={1050-6}
}
Switching the balance from rejection of major histocompatibility-mismatched grafts toward long-term tolerance of donor grafts, with the need for minimal immunosuppressive drugs, is a major transplantation goal. Regulatory T cells (Treg) can induce and maintain antigen-specific immune tolerance and facilitate allogeneic graft survival successfully in animals. This review will focus on the valuable insights experimental mouse models have given us into the effects of currently used… CONTINUE READING

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