Regulatory T cells in the periphery.

  title={Regulatory T cells in the periphery.},
  author={Jens Lohr and Birgit Knoechel and Abul K Abbas},
  journal={Immunological reviews},
Recognition of a systemic antigen by CD4+ T cells in a lymphopenic host leads to the sequential generation of pathogenic effector cells and protective CD25+ forkhead box protein (Foxp3+) regulatory T cells (Tregs) in the periphery. Such an experimental model is potentially valuable for defining the stimuli that determine the balance of effector and regulatory T cells. Our studies have shown that interleukin-2 (IL-2) enhances the development of effector cells and is essential for the peripheral… CONTINUE READING
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