Regulatory T cells in human autoimmune diseases

  title={Regulatory T cells in human autoimmune diseases},
  author={Troy R. Torgerson},
  journal={Springer Seminars in Immunopathology},
In the most simplistic terms, immune tolerance can be envisioned as a balance with autoreactive cells that arise naturally in all individuals on one side and regulatory mechanisms designed to counter those autoreactive processes on the other. A tilt of the balance toward the autoreactive side, either by increasing the number or function of autoreactive cells or by diminishing regulatory mechanisms, is manifested as autoimmunity. In contrast, tilting of the balance toward increased regulation… CONTINUE READING
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