Regulatory T cells in graft-versus-host disease

@article{Salomon2006RegulatoryTC,
  title={Regulatory T cells in graft-versus-host disease},
  author={Beno{\^i}t L. Salomon and Muriel Sudres and Jos{\'e} L. Cohen},
  journal={Springer Seminars in Immunopathology},
  year={2006},
  volume={28},
  pages={25-29}
}
Alloreactive T cells present in a bone marrow transplant are responsible for graft-vs-host disease, but their depletion is associated with impaired engraftment, immunosuppression, and loss of the graft-vs-leukemia effect. The subpopulation of CD4+CD25+ immunoregulatory T cells was first identified based on its crucial role in the control of autoimmune processes, but they also play a role in alloreactive responses. Moreover, these cells could be used to develop innovative strategies in the field… CONTINUE READING
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