Regulatory T cells in cattle and their potential role in bovine paratuberculosis.

  title={Regulatory T cells in cattle and their potential role in bovine paratuberculosis.},
  author={Paul M. Coussens and Sue S Sipkovsky and Brooke Murphy and Jon Roussey and Christopher J. Colvin},
  journal={Comparative immunology, microbiology and infectious diseases},
  volume={35 3},
The intracellular bacterium Mycobacterium avium subspecies paratuberculosis (MAP) causes Johne's disease in wild and domestic ruminants. Johne's disease presents as a chronic enteritis with severe inflammation of intestinal tissues, characterized by widespread infiltration of macrophages, the target cell of MAP. Clinical signs of Johne's disease are typically accompanied by a loss of peripheral CD4+ T cell responses to MAP antigens and an increase in anti-MAP serum IgG levels. Recently, it was… CONTINUE READING
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