Regulatory T cells in acute myelogenous leukemia: is it time for immunomodulation?

@article{Ustun2011RegulatoryTC,
  title={Regulatory T cells in acute myelogenous leukemia: is it time for immunomodulation?},
  author={Celalettin Ustun and Jeffrey S Miller and David H. Munn and Daniel J. Weisdorf and Bruce R Blazar},
  journal={Blood},
  year={2011},
  volume={118 19},
  pages={5084-95}
}
The microenviroment of acute myelogenous leukemia (AML) is suppressive for immune effector cells. Regulatory T cells (Tregs) have been recognized as a contributor factor and may be recruited and exploited by leukemic cells to evade immunesurveillance. Studies have shown that the frequencies of marrow and blood Tregs are greater in patients with AML than in control patients. Although increased Tregs have been associated with a decreased risk of GVHD after allogeneic HCT and hence may impede the… CONTINUE READING
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