Regulatory T cells control dendritic cell/NK cell cross-talk in lymph nodes at the steady state by inhibiting CD4+ self-reactive T cells.

@article{Terme2008RegulatoryTC,
  title={Regulatory T cells control dendritic cell/NK cell cross-talk in lymph nodes at the steady state by inhibiting CD4+ self-reactive T cells.},
  author={Magali Terme and Nathalie Chaput and B{\'e}hazine Combadi{\`e}re and Averil Ma and Toshiaki Ohteki and Laurence Zitvogel},
  journal={Journal of immunology},
  year={2008},
  volume={180 7},
  pages={
          4679-86
        }
}
  • Magali Terme, Nathalie Chaput, +3 authors Laurence Zitvogel
  • Published in Journal of immunology 2008
  • Biology, Medicine
  • The CD4(+)CD25(+)Foxp3(+) regulatory T cells (Treg) play an important role in the control of peripheral tolerance by directly inhibiting conventional T cell proliferative and effector functions. However, the mechanisms by which Treg regulate the homeostasis of lymph nodes remain unclear. In this study, we show in a mouse model that Treg control two major checkpoints dictated by the interaction between self-reactive CD4(+) T cells and resident dendritic cell (DC) in secondary lymphoid organs… CONTINUE READING

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