Regulatory T cells attenuate neuropathic pain following peripheral nerve injury and experimental autoimmune neuritis

@article{Austin2012RegulatoryTC,
  title={Regulatory T cells attenuate neuropathic pain following peripheral nerve injury and experimental autoimmune neuritis},
  author={Paul J Austin and Cristina Fabiola Kim and Chamini J. Perera and Gila Moalem-Taylor},
  journal={PAIN®},
  year={2012},
  volume={153},
  pages={1916-1931}
}
Neuroimmune crosstalk in neuropathic pain is a key contributor to pain hypersensitivity following nervous system injury. CD4+CD25+Foxp3+ regulatory T cells (Tregs) are endogenous immune suppressors, reducing T-cell proliferation and proinflammatory cytokine production. Currently, the role of Tregs in neuropathic pain is unknown. In this study, we tested the effects of expanding Tregs on pain hypersensitivity and neuroinflammation in 2 models of neuropathy; sciatic nerve chronic constriction… CONTINUE READING
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