Regulatory T cells: present facts and future hopes

  title={Regulatory T cells: present facts and future hopes},
  author={Christian D K Becker and Sabine Stoll and Tobias Bopp and Edgar Schmitt and Helmut Jonuleit},
  journal={Medical Microbiology and Immunology},
Naturally occurring CD4+CD25+Foxp3+ regulatory T cells and several subsets of induced suppressor T cells are key players of the immune tolerance network and control the induction and effector phase of our immunological defense system. These T cell populations actively control the properties of other immune cells by suppressing their functional activity to prevent autoimmunity and transplant rejection but also influence the immune response to allergens as well as against tumor cells and… CONTINUE READING