Regulatory T cells: history and perspective.

  title={Regulatory T cells: history and perspective.},
  author={Shimon Sakaguchi},
  journal={Methods in molecular biology},
Despite the skepticism that once prevailed among immunologists, it is now widely accepted that the normal immune system harbors a T-cell population, called regulatory T cells (Treg cells), specialized for immune suppression. It was first shown that depletion of a T-cell subpopulation from normal rodents produced autoimmune disease. Search for a molecular marker specific for such autoimmune-preventive Treg cells has revealed that the majority, if not all, of them constitutively express the CD25… CONTINUE READING