Regulatory T cell suppression and anergy are differentially regulated by proinflammatory cytokines produced by TLR-activated dendritic cells.

@article{Kubo2004RegulatoryTC,
  title={Regulatory T cell suppression and anergy are differentially regulated by proinflammatory cytokines produced by TLR-activated dendritic cells.},
  author={Takekazu Kubo and Robin D Hatton and Jason P Oliver and Xiaofen Liu and Charles O Elson and Casey T Weaver},
  journal={Journal of immunology},
  year={2004},
  volume={173 12},
  pages={
          7249-58
        }
}
CD25(+)CD4(+) regulatory T cells (Tregs) are required for the maintenance of peripheral tolerance to certain self Ags. In this study, the requirements for murine Treg-suppressive activity and proliferation were examined in the context of the maturation of myeloid dendritic cells (DCs). We find that the suppressive function of Tregs is critically dependent on immature DCs and is readily reversed by the maturation of DCs induced by GM-CSF, but does not require TLR activation of either DCs or… CONTINUE READING
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