Regulatory T-cell compartmentalization and trafficking.

  title={Regulatory T-cell compartmentalization and trafficking.},
  author={Shuang Wei and Ilona Kryczek and Weiping Zou},
  volume={108 2},
CD4(+)CD25(+)FOXP3(+) regulatory T cells (CD4(+) Treg cells) are thought to differentiate in the thymus and immigrate from the thymus to the periphery. Treg cells can regulate both acquired and innate immunity through multiple modes of suppression. The cross-talk between Treg cells and targeted cells, such as antigen-presenting cells (APCs) and T cells, is crucial for ensuring suppression by Treg cells in the appropriate microenvironment. Emerging evidence suggests that Treg… CONTINUE READING

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