Regulatory T-Cells in Pregnancy: Historical Perspective, State of the Art, and Burning Questions

@inproceedings{Ruocco2014RegulatoryTI,
  title={Regulatory T-Cells in Pregnancy: Historical Perspective, State of the Art, and Burning Questions},
  author={Maria Grazia Ruocco and G{\'e}rard Chaouat and L. M. Cordoba Florez and Armand Bensussan and David Klatzmann},
  booktitle={Front. Immunol.},
  year={2014}
}
In this review, we first revisit the original concept of "suppressor T-cells" in pregnancy, put it in a historical perspective, and then highlight the main data that licensed its resurrection and revision into the concept of "regulatory T-cells" (Tregs) in pregnancy. We review the evidence for a major role of Tregs in murine and human pregnancy and discuss Treg interactions with dendritic and uterine natural killer cells, other players of maternal-fetal tolerance. Finally, we highlight what we… CONTINUE READING

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Cutting edge : committed Th 1 CD 4 + T cell differentiation blocks pregnancyinduced Foxp 3 expression with antigen - specific fetal loss

  • L Xin, JM Ertelt, JH Rowe, TT Jiang, JM Kinder, V Chaturvedi
  • J Immunol
  • 2014

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