Regulatory T Cells and Immune Tolerance

@article{Sakaguchi2008RegulatoryTC,
  title={Regulatory T Cells and Immune Tolerance},
  author={S. Sakaguchi and Tomoyuki Yamaguchi and T. Nomura and M. Ono},
  journal={Cell},
  year={2008},
  volume={133},
  pages={775-787}
}
Regulatory T cells (Tregs) play an indispensable role in maintaining immunological unresponsiveness to self-antigens and in suppressing excessive immune responses deleterious to the host. Tregs are produced in the thymus as a functionally mature subpopulation of T cells and can also be induced from naive T cells in the periphery. Recent research reveals the cellular and molecular basis of Treg development and function and implicates dysregulation of Tregs in immunological disease. 
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