Regulatory T Cells and Human Myeloid Dendritic Cells Promote Tolerance via Programmed Death Ligand-1

@inproceedings{Amarnath2010RegulatoryTC,
  title={Regulatory T Cells and Human Myeloid Dendritic Cells Promote Tolerance via Programmed Death Ligand-1},
  author={Shoba Amarnath and Carliann M. Costanzo and Jacopo Mariotti and Jessica L. Ullman and William G. Telford and Veena Kapoor and James L Riley and Bruce L Levine and Carl H June and Timothy Fong and Noel L. Warner and Daniel H. Fowler},
  booktitle={PLoS biology},
  year={2010}
}
Immunotherapy using regulatory T cells (Treg) has been proposed, yet cellular and molecular mechanisms of human Tregs remain incompletely characterized. Here, we demonstrate that human Tregs promote the generation of myeloid dendritic cells (DC) with reduced capacity to stimulate effector T cell responses. In a model of xenogeneic graft-versus-host disease (GVHD), allogeneic human DC conditioned with Tregs suppressed human T cell activation and completely abrogated posttransplant lethality… CONTINUE READING
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