Regulatory T Cells Selectively Express Toll-like Receptors and Are Activated by Lipopolysaccharide

@article{Caramalho2003RegulatoryTC,
  title={Regulatory T Cells Selectively Express Toll-like Receptors and Are Activated by Lipopolysaccharide},
  author={Iris Caramalho and Thiago Lopes-Carvalho and Dominique Ostler and Santiago Zelenay and Matthias Haury and Jocelyne Demengeot},
  journal={The Journal of Experimental Medicine},
  year={2003},
  volume={197},
  pages={403 - 411}
}
Regulatory CD4 T cells (Treg) control inflammatory reactions to commensal bacteria and opportunist pathogens. Activation of Treg functions during these processes might be mediated by host-derived proinflammatory molecules or directly by bacterial products. We tested the hypothesis that engagement of germline-encoded receptors expressed by Treg participate in the triggering of their function. We report that the subset of CD4 cells known to exert regulatory functions in vivo (CD45RB(low) CD25… CONTINUE READING
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