Regulatory T Cell in Stroke: A New Paradigm for Immune Regulation

  title={Regulatory T Cell in Stroke: A New Paradigm for Immune Regulation},
  author={Sheng Chen and Haijian Wu and Damon W Klebe and Yuan Hong and Jianmin Zhang and Jiping Tang},
  booktitle={Clinical & developmental immunology},
Stroke is a common, debilitating trauma that has an incompletely elucidated pathophysiology and lacks an effective therapy. FoxP3(+)CD25(+)CD4(+) regulatory T cells (Tregs) suppress a variety of normal physiological and pathological immune responses via several pathways, such as inhibitory cytokine secretion, direct cytolysis induction, and antigen-presenting cell functional modulation. FoxP3(+)CD25(+)CD4(+) Tregs are involved in a variety of central nervous system diseases and injuries… CONTINUE READING
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