Regulatory RNAs and the HptB/RetS signalling pathways fine-tune Pseudomonas aeruginosa pathogenesis

@inproceedings{Bordi2010RegulatoryRA,
  title={Regulatory RNAs and the HptB/RetS signalling pathways fine-tune Pseudomonas aeruginosa pathogenesis},
  author={Christophe Bordi and Marie-C{\'e}cile Lamy and Isabelle Ventre and Elise Termine and Abderrahman Hachani and Sandy Fillet and B{\'e}atrice Roche and Sophie Bleves and Vincent M{\'e}jean and Andr{\'e}e M. Lazdunski and Alain Filloux},
  booktitle={Molecular microbiology},
  year={2010}
}
Bacterial pathogenesis often depends on regulatory networks, two-component systems and small RNAs (sRNAs). In Pseudomonas aeruginosa, the RetS sensor pathway downregulates expression of two sRNAs, rsmY and rsmZ. Consequently, biofilm and the Type Six Secretion System (T6SS) are repressed, whereas the Type III Secretion System (T3SS) is activated. We show that the HptB signalling pathway controls biofilm and T3SS, and fine-tunes P. aeruginosa pathogenesis. We demonstrate that RetS and HptB… CONTINUE READING