Regulatory Effects of Reboxetine Treatment Alone, or Following Paroxetine Treatment, on Brain Noradrenergic and Serotonergic Systems

@article{Gould2003RegulatoryEO,
  title={Regulatory Effects of Reboxetine Treatment Alone, or Following Paroxetine Treatment, on Brain Noradrenergic and Serotonergic Systems},
  author={Georgianna G Gould and Marie-Christine Pardon and David A Morilak and Alan Frazer},
  journal={Neuropsychopharmacology},
  year={2003},
  volume={28},
  pages={1633-1641}
}
When patients do not respond to an initial antidepressant, one clinical approach is to switch to an agent in a different pharmacological class. However, few studies have examined the neurochemical consequences of this practice. To study this, we examined changes in binding sites in rat brain for norepinephrine (NET) and serotonin transporters (SERT), α1, α2, and β1 adrenergic receptors after chronic administration of paroxetine (PRX), reboxetine (RBX), or PRX followed by RBX. We also examined… CONTINUE READING
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