Regulatory Effect of Hydrogen Sulfide on Vascular Collagen Content in Spontaneously Hypertensive Rats

@article{Zhao2008RegulatoryEO,
  title={Regulatory Effect of Hydrogen Sulfide on Vascular Collagen Content in Spontaneously Hypertensive Rats},
  author={Xia Zhao and Li-ke Zhang and Chun-yu Zhang and Xiang-jun Zeng and Hui Chao Yan and Hong-fang Jin and Chao-shu Tang and Junbao Du},
  journal={Hypertension Research},
  year={2008},
  volume={31},
  pages={1619-1630}
}
The present study aimed to examine the regulatory effect of hydrogen sulfide (H2S) on vascular collagen remodeling in hypertensive rats. After 5 weeks of H2S donor treatment, tail blood pressure, the endogenous H2S production rate, levels of hydroxyproline and collagen type I, collagen type I protein expression in the thoracic aorta, [3H]thymidine ([3H]TdR) incorporation, [3H]proline incorporation, and [3H]hydroxyproline secretion in cultured vascular smooth muscle cells (VSMCs) were measured… CONTINUE READING
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