Regulatory Domains and Their Mechanisms.

  title={Regulatory Domains and Their Mechanisms.},
  author={Nezha S. Benabdallah and Wendy A. Bickmore},
  journal={Cold Spring Harbor symposia on quantitative biology},
The concept of gene regulation is being refined as our understanding of the role of enhancer elements grows. Although described more than 30 years ago, the mechanisms through which these cis-regulating elements operate remain under debate. With the recognition that most of the human genetic variation contributing to common disease risk lies outside of genes and probably in enhancers, unraveling these mechanisms becomes ever more important. Originally, a popular view was to consider regulatory… CONTINUE READING