Regulatory Domain Selectivity in the Cell-Type Specific PKN-Dependence of Cell Migration

@inproceedings{Lachmann2011RegulatoryDS,
  title={Regulatory Domain Selectivity in the Cell-Type Specific PKN-Dependence of Cell Migration},
  author={Sylvie Lachmann and Amy Jevons and Manu De Rycker and Adele Casamassima and Simone Radtke and Alejandra Collazos and Peter J Parker},
  booktitle={PloS one},
  year={2011}
}
The mammalian protein kinase N (PKN) family of Serine/Threonine kinases comprises three isoforms, which are targets for Rho family GTPases. Small GTPases are major regulators of the cellular cytoskeleton, generating interest in the role(s) of specific PKN isoforms in processes such as cell migration and invasion. It has been reported that PKN3 is required for prostate tumour cell invasion but not PKN1 or 2. Here we employ a cell model, the 5637 bladder tumour cell line where PKN2 is relatively… CONTINUE READING