Regulatory Conformational Coupling between CLC Anion Channel Membrane and Cytoplasmic Domains.

@article{Yamada2016RegulatoryCC,
  title={Regulatory Conformational Coupling between CLC Anion Channel Membrane and Cytoplasmic Domains.},
  author={Toshiki Yamada and K. Strange},
  journal={Biophysical journal},
  year={2016},
  volume={111 9},
  pages={
          1887-1896
        }
}
CLC anion channels are homodimeric proteins. Each subunit is comprised of 18 α-helices designated "A-R" and an intracellular carboxy-terminus containing two cystathionine-β-synthase (CBS1 and CBS2) domains. Conformational coupling between membrane and intracellular domains via poorly understood mechanisms is required for CLC regulation. The activity of the C. elegans CLC channel CLH-3b is reduced by phosphorylation of a carboxy-terminus "activation domain," which disrupts its interaction with… Expand

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