Regulatory B cells shape the development of Th2 immune responses in BALB/c mice infected with Leishmania major through IL-10 production.

@article{Ronet2010RegulatoryBC,
  title={Regulatory B cells shape the development of Th2 immune responses in BALB/c mice infected with Leishmania major through IL-10 production.},
  author={Catherine Ronet and Yazmin Hauyon-La Torre and M{\'e}lanie Revaz-Breton and B{\'e}atris Mastelic and Fabienne Tacchini-Cottier and Jacques Louis and Pascal Launois},
  journal={Journal of immunology},
  year={2010},
  volume={184 2},
  pages={886-94}
}
Recent evidence indicates that B cells are required for susceptibility to infection with Leishmania major in BALB/c mice. In this study, we analyzed the role of the IL-10 produced by B cells in this process. We showed that B cells purified from the spleen of BALB/c mice produced IL-10 in response to stimulation with L. major in vitro. In vivo, early IL-10 mRNA expression is detected after L. major infection in B cells from draining lymph nodes of susceptible BALB/c, but not of resistant C57BL/6… CONTINUE READING