Regulatory B cells inhibit EAE initiation in mice while other B cells promote disease progression.

  title={Regulatory B cells inhibit EAE initiation in mice while other B cells promote disease progression.},
  author={Takashi Matsushita and Koichi Yanaba and Jean-David Bouaziz and Manabu Fujimoto and Thomas F. Tedder},
  journal={The Journal of clinical investigation},
  volume={118 10},
EAE is a mouse T cell-mediated autoimmune disease of the CNS used to model the human condition MS. The contributions of B cells to EAE initiation and progression are unclear. In this study, we have shown that EAE disease initiation and progression are differentially influenced by the depletion of B cells from mice with otherwise intact immune systems. CD20 antibody-mediated B cell depletion before EAE induction substantially exacerbated disease symptoms and increased encephalitogenic T cell… CONTINUE READING
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