Regulatory B cells in anti-tumor immunity.

  title={Regulatory B cells in anti-tumor immunity.},
  author={Yu Zhang and Nicolas Gallastegui and Joseph D. Rosenblatt},
  journal={International immunology},
  volume={27 10},
Advances in understanding of the immune microenvironment have highlighted the role of immunosuppressive T cell, myeloid, dendritic and monocytic sub-populations in inhibition of the anti-tumor immune response. The role of B cells in modulating the immune response to solid tumors as well as lymphoid malignancies is less well understood. Murine models of autoimmune disease have defined B regulatory cell (Breg) subsets with immune suppressive activity, including B cell subsets that express IL-10… CONTINUE READING
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