Regulators of apoptosis: suitable targets for immune therapy of cancer

  title={Regulators of apoptosis: suitable targets for immune therapy of cancer},
  author={Mads Hald Andersen and J{\"u}rgen C Becker and P Straten},
  journal={Nature Reviews Drug Discovery},
Harnessing the immune system in the battle against cancer has been the focus of tremendous research efforts during the past two decades. Several means for achieving this goal, including adoptive transfer of tumour-reactive T cells, systemic or localized administration of immune modulating cytokines and the use of 'therapeutic' vaccines, have been explored. Anti-apoptotic molecules that enhance the survival of cancer cells and facilitate their escape from cytotoxic therapies represent prime… CONTINUE READING
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