Regulators of G protein signaling (RGS proteins): novel central nervous system drug targets.

  title={Regulators of G protein signaling (RGS proteins): novel central nervous system drug targets.},
  author={Richard R. Neubig},
  journal={The journal of peptide research : official journal of the American Peptide Society},
  volume={60 6},
Many drugs of abuse signal through receptors that couple to G proteins (GPCRs), so the factors that control GPCR signaling are likely to be important to the understanding of drug abuse. Contributions by the recently identified protein family, regulators of G protein signaling (RGS) to the control of GPCR function are just beginning to be understood. RGS proteins can accelerate the deactivation of G proteins by 1000-fold and in cell systems they profoundly inhibit signaling by many receptors… CONTINUE READING

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