Regulators of G protein signaling & drugs of abuse.

  title={Regulators of G protein signaling & drugs of abuse.},
  author={John R. Traynor and Richard R. Neubig},
  journal={Molecular interventions},
  volume={5 1},
Drugs of abuse such as opioids and stimulants share a common dopaminergic reward pathway; however, in response to continual intermittent exposure to such drugs, there are neuronal alterations leading to changes in behavior. Regulators of G protein signaling (RGS) are proteins that negatively regulate G protein signaling and are expressed in brain areas important for the pharmacology of abused drugs. Moreover, the level of expression of several of these proteins is regulated by abused drugs. In… CONTINUE READING

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