Regulators of G Protein Signaling Attenuate the G Protein–mediated Inhibition of N-Type Ca Channels

@article{Melliti1999RegulatorsOG,
  title={Regulators of G Protein Signaling Attenuate the G Protein–mediated Inhibition of N-Type Ca Channels },
  author={Karim Melliti and Ulises Meza and Rory A Fisher and Brett Adams},
  journal={The Journal of General Physiology},
  year={1999},
  volume={113},
  pages={97 - 110}
}
Regulators of G protein signaling (RGS) proteins bind to the alpha subunits of certain heterotrimeric G proteins and greatly enhance their rate of GTP hydrolysis, thereby determining the time course of interactions among Galpha, Gbetagamma, and their effectors. Voltage-gated N-type Ca channels mediate neurosecretion, and these Ca channels are powerfully inhibited by G proteins. To determine whether RGS proteins could influence Ca channel function, we recorded the activity of N-type Ca channels… CONTINUE READING