Regulation of yAP-1 nuclear localization in response to oxidative stress.

  title={Regulation of yAP-1 nuclear localization in response to oxidative stress.},
  author={Shusuke Kuge and Nic Jones and A. Nomoto},
  journal={The EMBO journal},
  volume={16 7},
The YAP1 gene of Saccharomyces cerevisiae encodes a bZIP-containing transcription factor that is essential for the normal response of cells to oxidative stress. Under stress conditions, the activity of yAP-1 is increased, leading to the induced expression of a number of target genes encoding protective enzymes or molecules. We have examined the mechanism of this activation. Upon imposition of oxidative stress, a small increase in the DNA-binding capacity of yAP-1 occurs. However, the major… CONTINUE READING
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