Regulation of xanthine dehydrogenase and xanthine oxidase activity by hypoxia.

@article{Poss1996RegulationOX,
  title={Regulation of xanthine dehydrogenase and xanthine oxidase activity by hypoxia.},
  author={William Bradley Poss and Thomas P. Huecksteadt and Peter C. Panus and Bruce A. Freeman and John R. Hoidal},
  journal={The American journal of physiology},
  year={1996},
  volume={270 6 Pt 1},
  pages={L941-6}
}
The present study determined the effect of hypoxia on xanthine dehydrogenase (XDH) and xanthine oxidase (XO) activity and gene and protein expression in cultured bovine aortic endothelial cells (BAEC). BAEC were exposed to hypoxia (3% O2) or anoxia (0% O2) for 24 or 48 h and to 24 h of hypoxia followed by 24 h of reoxygenation. Hypoxia- and anoxia-exposed BAEC demonstrated a greater than twofold increase in XDH/XO activity at 24 and 48 h compared with timed controls. Hypoxic cells that were… CONTINUE READING

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