Regulation of white-opaque switching in Candida albicans

@article{Morschhuser2010RegulationOW,
  title={Regulation of white-opaque switching in Candida albicans},
  author={Joachim Morschh{\"a}user},
  journal={Medical Microbiology and Immunology},
  year={2010},
  volume={199},
  pages={165-172}
}
  • J. Morschhäuser
  • Published 14 April 2010
  • Biology, Medicine
  • Medical Microbiology and Immunology
The yeast Candida albicans is part of the microflora in most healthy people, but can become a pathogen when host defenses are compromised. The phenotypic plasticity of C. albicans, which includes switching between different morphologies, contributes to its ability to colonize and infect virtually all body locations. A particularly fascinating developmental program is white-opaque switching, a reversible transition between the normal yeast morphology (white) and an elongated cell type (opaque… Expand
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The results suggest that, depending on the environment, white-opaque switching enables C. albicans to escape from specific host defense mechanisms. Expand
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An expanded role is demonstrated for C. tropicalis Wor1, including the regulation of processes necessary for infection of the mammalian host, in light of the ancestral role of Wor1 as a transcriptional regulator of the transition between yeast form and filamentous growth. Expand
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TLDR
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A population shift between two heritable cell types of the pathogen Candida albicans is based both on switching and selective proliferation
TLDR
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TLDR
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TLDR
It is found that in strain WO-1, a strain in which genomic alterations have occurred, but not in other tested strains, switching from the white to the opaque phase can also be induced by environmental conditions, demonstrating that switching and mating of C. albicans may occur with high efficiency in appropriate niches within its human host. Expand
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TLDR
A model for how changes in cellular growth modulate white-opaque switching frequencies is proposed, based on the sensitivity of the switch to levels of the master regulator Wor1, which shows a wide range of factors induces high rates of switching from white to opaque. Expand
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TLDR
This work reviews recent work on white-opaque switching, including the establishment of the transcriptional circuit underlying this switch, the identification of environmental signals that affect switching rates, newly discovered differences between the two types of cells, and the involvement of white-opsaque switching in biofilm formation. Expand
CO2 Regulates White-to-Opaque Switching in Candida albicans
TLDR
It is suggested that the high levels of CO(2) in the host induce and stabilize the opaque phenotype, thus facilitating mating, and this work tested the possibility that CO( 2) stabilizes the opacity of Candida albicans. Expand
Epigenetic properties of white–opaque switching in Candida albicans are based on a self-sustaining transcriptional feedback loop
TLDR
It is shown that in opaque cells, Wor1 forms a positive feedback loop: It binds its own DNA regulatory region and activates its own transcription leading to the accumulation of high levels of Wor1, and this feedback loop is self-sustaining. Expand
White-Opaque Switching in Candida albicans Is Controlled by Mating-Type Locus Homeodomain Proteins and Allows Efficient Mating
TLDR
It is shown that opaque cells are a mating-competent form of C. albicans and that this pathogen undergoes a white-to-opaque switch as a critical step in the mating process. Expand
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TLDR
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TLDR
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TLDR
Wor1 (white–opaque regulator 1) is identified as a master regulator of white-opaque switching and genetic evidence for feedback regulation of WOR1 transcription is presented, explaining the bistable and stochastic nature of white–opaques switching. Expand
Control of White-Opaque Phenotypic Switching inCandida albicans by the Efg1p Morphogenetic Regulator
TLDR
Evidence is presented that phenotypic switching in Candida albicans is regulated by the Efg1 protein, which is known as an essential element of hyphal development (dimorphism), and results suggest that high EFG1expression levels induce and maintain the white cell form while lowEFG1 expression levels induceand maintain the opaque cell form. Expand
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