Regulation of von Willebrand factor-platelet interactions.

  title={Regulation of von Willebrand factor-platelet interactions.},
  author={Peter J Lenting and Julie N. Pegon and Evelyn Groot and Philip G. de Groot},
  journal={Thrombosis and haemostasis},
  volume={104 3},
The formation of thrombi is a multistep process involving several components, including von Willebrand factor (VWF). VWF is an adhesive multimeric protein, which acts as a molecular bridge between the subendothelial matrix and the glycoprotein Ib/IX/V receptor complex. Furthermore, VWF promotes the expansion of the platelet plug by cross-linking platelets via binding to integrin alphaIIbbeta3. In terms of thrombus formation, it is essential that VWF-platelet interactions occur timely, that is… CONTINUE READING

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