Regulation of volume-sensitive outwardly rectifying anion channels in pulmonary arterial smooth muscle cells by PKC.

@article{Zhong2002RegulationOV,
  title={Regulation of volume-sensitive outwardly rectifying anion channels in pulmonary arterial smooth muscle cells by PKC.},
  author={Juming Zhong and Ge-xin Wang and William J. Hatton and Ilia A. Yamboliev and M. P. Walsh and Joseph R. Hume},
  journal={American journal of physiology. Cell physiology},
  year={2002},
  volume={283 6},
  pages={C1627-36}
}
We tested the possible role of endogenous protein kinase C (PKC) in the regulation of native volume-sensitive organic osmolyte and anion channels (VSOACs) in acutely dispersed canine pulmonary artery smooth muscle cells (PASMC). Hypotonic cell swelling activated native volume-regulated Cl(-) currents (I(Cl.vol)) which could be reversed by exposure to phorbol 12,13-dibutyrate (0.1 microM) or by hypertonic cell shrinkage. Under isotonic conditions, calphostin C (0.1 microM) or Ro-31-8425 (0.1… CONTINUE READING

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