Regulation of voltage-gated Ca2+ channels by calmodulin.

  title={Regulation of voltage-gated Ca2+ channels by calmodulin.},
  author={David B. Halling and Paula Aracena-Parks and Susan L. Hamilton},
  journal={Science's STKE : signal transduction knowledge environment},
  volume={2006 318},
Calmodulin, a highly versatile and ubiquitously expressed Ca2+ sensor, regulates the function of many enzymes and ion channels. Both Ca2+-dependent inactivation and Ca2+-dependent facilitation of the voltage-gated Ca2+ channels Cav1.2 andCav2.1 are regulated through an interaction with Ca2+-bound calmodulin. This review addresses the functional regulation of Cav1.2 and Cav2.1 by calmodulin and discusses how Ca2+ binding to a single calmodulin molecule can regulate opposing functions of the… CONTINUE READING

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