Regulation of voltage-dependent calcium channels by RGK proteins.

  title={Regulation of voltage-dependent calcium channels by RGK proteins.},
  author={Tingting Yang and Henry M Colecraft},
  journal={Biochimica et biophysica acta},
  volume={1828 7},
RGK proteins belong to the Ras superfamily of monomeric G-proteins, and currently include four members - Rad, Rem, Rem2, and Gem/Kir. RGK proteins are broadly expressed, and are the most potent known intracellular inhibitors of high-voltage-activated Ca²⁺ (Ca(V)1 and Ca(V)2) channels. Here, we review and discuss the evidence in the literature regarding the functional mechanisms, structural determinants, physiological role, and potential practical applications of RGK-mediated inhibition of Ca(V… CONTINUE READING


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