Regulation of vitamin D receptor function in MEN1-related parathyroid adenomas.

  title={Regulation of vitamin D receptor function in MEN1-related parathyroid adenomas.},
  author={Koen M. A. Dreijerink and Radhika A. Varier and Rick van Nuland and Roel Broekhuizen and G. D. Valk and Jacqueline E van der Wal and C. J. Lips and Jean Alain Kummer and H. Th. Marc Timmers},
  journal={Molecular and cellular endocrinology},
  volume={313 1-2},
Multiple endocrine neoplasia type 1 (MEN1) is a heriditary syndrome characterised by the occurrence of parathyroid, gastroenteropancreatic and pituitary tumours. The MEN1 gene product, menin, co-activates gene transcription by recruiting histone methyltransferases for lysine 4 of histone H3 (H3K4). We investigated whether in MEN1 tumours global changes in H3K4 trimethylation (H3K4me3) occur or whether alterations in gene expression can be observed. By immunohistochemistry we found that global… CONTINUE READING


Publications citing this paper.
Showing 1-9 of 9 extracted citations


Publications referenced by this paper.

Nature 435 , 1262 – 1266

  • S. Horvath, T. Shi, H. Yu, S. Tze, M. Grunstein

Similar Papers

Loading similar papers…