Regulation of vitamin D receptor expression via estrogen-induced activation of the ERK 1/2 signaling pathway in colon and breast cancer cells.

@article{Gilad2005RegulationOV,
  title={Regulation of vitamin D receptor expression via estrogen-induced activation of the ERK 1/2 signaling pathway in colon and breast cancer cells.},
  author={Liat Abovich Gilad and Tali Bresler and Julia Gnainsky and Patricia Smirnoff and Betty Schwartz},
  journal={The Journal of endocrinology},
  year={2005},
  volume={185 3},
  pages={
          577-92
        }
}
We previously demonstrated that 17beta-estradiol (E2) regulates the transcription and expression of the vitamin D receptor (VDR) in rat colonocytes and duodenocytes in vivo. The aim of the present study was to assess whether the extracellular signal-regulated kinase (ERK) induced by E2 is involved in regulating VDR expression. We compared E2-associated signaling activity in HT29 colon cancer cells, a non-classical E2-target, with that in MCF-7 breast cancer cells, the natural targets of the… CONTINUE READING

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Vitamin D and breast cancer.

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References

Publications referenced by this paper.
SHOWING 1-10 OF 74 REFERENCES

Sulindac sulfide inhibits Ras signaling

VIEW 8 EXCERPTS
HIGHLY INFLUENTIAL

Detection of estrogen receptor-beta mRNA in breast cancer using RT-PCR.

  • The International journal of biological markers
  • 2000
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Estrogen action via the cAMP signaling pathway: stimulation of adenylate cyclase and cAMP-regulated gene transcription.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 1994
VIEW 2 EXCERPTS
HIGHLY INFLUENTIAL