Regulation of vitamin D receptor abundance and responsiveness during differentiation of HT-29 human colon cancer cells.

@article{Zhao1993RegulationOV,
  title={Regulation of vitamin D receptor abundance and responsiveness during differentiation of HT-29 human colon cancer cells.},
  author={X Y Zhao and David Feldman},
  journal={Endocrinology},
  year={1993},
  volume={132 4},
  pages={1808-14}
}
We have studied the effects of 1,25-dihydroxyvitamin D [1,25-(OH)2D3] on cellular differentiation in the HT-29 human colon cancer cell line. Our aim was to evaluate the regulation of 1,25-dihydroxyvitamin D receptor (VDR) abundance and hormone responsiveness during the transition of rapidly proliferating to differentiated cells. Differentiation was induced by three means: cells were cultured in galactose-supplemented medium without glucose (GAL), grown on Matrigel-coated surfaces (MTG), or… CONTINUE READING
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