Regulation of virulence gene expression in Streptococcus pyogenes: determinants of differential mRNA decay.

@article{Bugrysheva2010RegulationOV,
  title={Regulation of virulence gene expression in Streptococcus pyogenes: determinants of differential mRNA decay.},
  author={Julia V. Bugrysheva and June R. Scott},
  journal={RNA biology},
  year={2010},
  volume={7 5},
  pages={569-72}
}
Differential mRNA stability is an important mechanism for regulation of virulence factors in Streptococcus pyogenes (group A streptococcus, GAS), a serious and prevalent human pathogen. We have described 2 Classes of mRNA in GAS that are distinguishable by 1) stability in the stationary phase of growth, 2) kinetics of decay in exponential phase, and 3) effect of depletion of RNases J1 and J2 and polynucleotide phosphorylase (PNPase) on decay in exponential phase. We discuss features of the… CONTINUE READING