Regulation of vascular tone and remodeling of the ductus arteriosus.

  title={Regulation of vascular tone and remodeling of the ductus arteriosus.},
  author={Utako Yokoyama and Susumu Minamisawa and Yoshihiro Ishikawa},
  journal={Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi},
  volume={46 2},
The ductus arteriosus (DA), a fetal arterial connection between the main pulmonary artery and the descending aorta, normally closes immediately after birth. The DA is a normal and essential fetal structure. However, it becomes abnormal if it remains patent after birth. Closure of the DA occurs in two phases: functional closure of the lumen within the first hours after birth by smooth muscle constriction, and anatomic occlusion of the lumen over the next several days due to extensive neointimal… CONTINUE READING
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