Regulation of vascular smooth muscle cell expression and function of matrix metalloproteinases is mediated by estrogen and progesterone exposure.

@article{Grandas2009RegulationOV,
  title={Regulation of vascular smooth muscle cell expression and function of matrix metalloproteinases is mediated by estrogen and progesterone exposure.},
  author={Oscar Grandas and Deidra Mountain and Stacy Kirkpatrick and David C. Cassada and Scott L. Stevens and Michael B. Freeman and Mitchell H. Goldman},
  journal={Journal of vascular surgery},
  year={2009},
  volume={49 1},
  pages={185-91}
}
OBJECTIVE Postmenopausal women receiving hormone replacement therapy (HRT) have been reported to have more adverse outcomes after vascular reconstructions, including increased intimal hyperplasia development and bypass graft failure. HRT may be affecting the pathway contributing to intimal hyperplasia. An important component of this pathway involves matrix metalloproteinases (MMPs), implicated in vascular remodeling due to their ability to degrade components of the extracellular matrix. We… CONTINUE READING